this is a sweet well thought out detailed pre-planned project. engine is too far forward in the chassis vs the chevy. I don't think there's any way around moving the engine back about a foot, or moving the axle forward just as much.
now I know why VANS.
back to thinking about that other frame if there's drivetrain moves needed anyway. Zero other advantages to it: the lug pattern on there is useless, it's specific to just f450/f550 of a pretty narrow range of years (99 to 03/04?) so no wheel other than stock 19.5, and unlikely to find used adaptors to anything else. 8x225, rather than the 10x225 of everything else heavy+modern. There are some 22.5 tires that are a very good size match (235/80r22.5 is almost the same as the 8r20 on it now), but 22.5 HD stuff is 10x285. no cheap steel take-offs sitting around from anything.
It would take as much work on the '50 frame to beef it up enough for modern power and brakes as it would to move the engine.
Shame steel is so expensive now. starting from scratch has sudden appeal.